Colocalization of androgen receptors and mating-induced FOS immunoreactivity in neurons that project to the central tegmental field in male rats

ABSTRACT The results of this study confirm our previous report of increased androgen receptor expression in livers of female SUAH Wistar rats during development of liver tumours induced by diethylnitrosamine (DENA). In adult female rats not treated with DENA, removal of the ovary increased liver androgen receptor levels but testosterone did not further enhance the androgen receptor status of ovariectomized rats. In normal adult males the testis and/or testosterone maintained high levels of androgen receptors but oestrogen reduced them in castrated rats. Oestrogen receptor levels were not significantly changed in either males or females by gonadectomy. Treatment of female rats with DENA for 10 and 16 weeks increased liver androgen receptors but oestrogen receptors were only reduced by 16 weeks of DENA treatment, whether the rats were intact or ovariectomized. Concentrations of liver androgen receptors were increased in intact and castrated male rats by 10 and 16 weeks of DENA treatment, an increase not seen in the previous experiments. Oestrogen appeared to inhibit both the increases in liver androgen receptor expression and liver tumour development in rats treated with the weakly carcinogenic dose of 10 weeks of DENA. However, the full carcinogenic dose of 16 weeks of DENA increased liver androgen receptors and decreased oestrogen receptors in female rats regardless of sex-steroid status. Development of malignant hepatocellular carcinoma (HCC) was associated with both an increase in liver androgen receptors and a decrease in oestrogen receptors. Maintenance of relatively high levels of liver oestrogen receptors appeared to protect the liver against development of HCC.

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Development of a Vagina in Male Rats by Inhibiting Androgen Receptors with an Anti-androgen During the Critical Phase of Organogenesis

Endocrinology ◽

10.1210/endo-78-3-628 ◽

1966 ◽

Vol 78 (3) ◽

pp. 628-632 ◽

Cited By ~ 55

Author(s):

F. NEUMANN ◽

W. ELGER ◽

M. KRAMER

Keyword(s):

Androgen Receptors ◽

Male Rats ◽

Critical Phase

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Effect of Methyltrienolone on the Metabolic Disorders in Rat Model of Alloxan-Induced Diabetes

European Scientific Journal ESJ ◽

10.19044/esj.2017.v13n15p22 ◽

2017 ◽

Vol 13 (15) ◽

pp. 22

Author(s):

Neli Didebulidze MBiol ◽

Sopiko Kandelaki ◽

Manana Kakabadze ◽

Salome Kordzaia ◽

Dimitri Kordzaia ◽

...

Keyword(s):

Rna Synthesis ◽

Androgen Receptors ◽

Control Level ◽

Intraperitoneal Administration ◽

Receptor Expression ◽

Male Rats ◽

Control Group ◽

Dna And Rna ◽

Hormonal Dysfunction ◽

Metabolic Imbalance

Aim: The aim of the study was to investigate the restoration of metabolic imbalance related with deficiency of insulin by the exogenous androgen supplementation in the experimental model of alloxan-induced diabetes in Wistar male rats. Methods: The experimental diabetes was induced by a single intraperitoneal administration of alloxan. The concentrations of glucose, immunereactive insulin, corticosterone, testosterone and estradiol were examined in blood, the intensity of DNA and RNA synthesis and androgen receptor expression were studied in the liver tissue – at 15th, 30th and 45th days of alloxan-induced diabetes. The synthetic androgen methyltrienolone was administered to rats with 30-days diabetes during 15 days. All data were compared to control group received solvent. Results: The induction of diabetes increased the concentrations of glucose, corticosterone and estradiol while decreases insulin and testosterone concentration in blood as well as DNA/RNA synthesis and androgen receptors expression in hepatocytes. The administration of exogenous androgen significantly restored the metabolic imbalance and the expression of androgen receptors and increased DNA/RNA synthesis in liver cells maintained close to control level. Conclusion: The administration of methyltrienolone reduced the effect of “diabetic stress” and restored the hormonal dysfunction induced by alloxan.

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Immunohistochemical identification of androgen receptors in the liver of pubertal male rats

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf02445159 ◽

1996 ◽

Vol 122 (2) ◽

pp. 823-826

Author(s):

I. V. Kovtun ◽

A. N. Smirnov ◽

V. B. Turovetskii ◽

O. V. Smirnova

Keyword(s):

Androgen Receptors ◽

Male Rats ◽

Immunohistochemical Identification

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ANDROGEN RECEPTORS IN THE RAT BRAIN, ANTERIOR PITUITARY GLAND AND VENTRAL PROSTATE GLAND: EFFECTS OF ORCHIDECTOMY AND AGEING

Journal of Endocrinology ◽

10.1677/joe.0.0810075 ◽

1979 ◽

Vol 81 (1) ◽

pp. 75-81 ◽

Cited By ~ 36

Author(s):

B. D. GREENSTEIN

Keyword(s):

Pituitary Gland ◽

Binding Sites ◽

Anterior Pituitary ◽

Androgen Receptors ◽

Prostate Gland ◽

Anterior Pituitary Gland ◽

Male Rats ◽

Ventral Prostate ◽

Binding Reaction ◽

Old Rats

Available high-affinity binding sites for 5α-dihydrotestosterone (DHT) were measured in cytosols obtained from the amygdala, hypothalamus, anterior pituitary gland and ventral prostate gland of 12-week-old rats at various times after orchidectomy, and in the corresponding tissues of 18-month-old male rats. It is suggested that the lower affinity of the DHT binding reaction in brain and ventral prostatic cytosols after orchidectomy or ageing respectively, may explain, at least in part, the changes in the responsiveness of the tissues to androgens.

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